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Showing posts with label changes. Show all posts

Regular exercise changes the brain to improve memory, thinking skills

6:47 AM Posted by Rhoda , , , , , , ,

There are plenty of good reasons to be physically active. Big ones include reducing the odds of developing heart disease, stroke, and diabetes. Maybe you want to lose weight, lower your blood pressure, prevent depression, or just look better. Here’s another one, which especially applies to those of us (including me) experiencing the brain fog that comes with age: exercise changes the brain in ways that protect memory and thinking skills.

In a study done at the University of British Columbia, researchers found that regular aerobic exercise, the kind that gets your heart and your sweat glands pumping, appears to boost the size of the hippocampus, the brain area involved in verbal memory and learning. Resistance training, balance and muscle toning exercises did not have the same results. The results were published this week in the British Journal of Sports Medicine.

The finding comes at a critical time. Researchers say one new case of dementia is detected every four seconds globally. They estimate that by the year 2050, more than 115 million people will have dementia worldwide.

Exercise and the brain

As I write in the May 2014 Harvard Health Letter, exercise helps memory and thinking through both direct and indirect means. The benefits of exercise come directly from its ability to reduce insulin resistance, reduce inflammation, and stimulate the release of growth factors—chemicals in the brain that affect the health of brain cells, the growth of new blood vessels in the brain, and even the abundance and survival of new brain cells.

Indirectly, exercise improves mood and sleep, and reduces stress and anxiety. Problems in these areas frequently cause or contribute to cognitive impairment.

Many studies have suggested that the parts of the brain that control thinking and memory (the prefrontal cortex and medial temporal cortex) have greater volume in people who exercise versus people who don’t. “Even more exciting is the finding that engaging in a program of regular exercise of moderate intensity over six months or a year is associated with an increase in the volume of selected brain regions,” says Dr. Scott McGinnis, a neurologist at Brigham and Women’s Hospital and an instructor in neurology at Harvard Medical School.

Put it to the test

So what should you do? Start exercising! We don’t know exactly which exercise is best. Almost all of the research has looked at walking, including the latest study. “It’s likely that other forms of aerobic exercise that get your heart pumping might yield similar benefits,” says Dr. McGinnis.

How much exercise is required? The study participants walked briskly for one hour, twice a week. That’s 120 minutes of moderate intensity exercise a week. Standard recommendations advise half an hour of moderate physical activity most days of the week, or 150 minutes a week. If that seems daunting, start with a few minutes a day, and increase the amount you exercise by five or 10 minutes every week until you reach your goal.

If you don’t want to walk, consider other moderate-intensity exercises, such as swimming, stair climbing, tennis, squash, or dancing. Don’t forget that household activities can count as well, such as intense floor mopping, raking leaves, or anything that gets your heart pumping so much that you break out in a light sweat.

Don’t have the discipline to do it on your own? Try any or all of these ideas:

  • Join a class or work out with a friend who’ll hold you accountable.
  • Track your progress, which encourages you to reach a goal.
  • If you’re able, hire a personal trainer. (Paying an expert is good motivation.)

Whatever exercise and motivators you choose, commit to establishing exercise as a habit, almost like taking a prescription medication. After all, they say that exercise is medicine, and that can go on the top of anyone’s list of reasons to work out.



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No evidence of Alzheimer's disease related changes in young people carry genetic risk factors

2:14 AM Posted by Rhoda , , , , , , , , ,

Of the apolipoprotein (ApoE) ?4 allele are at increased risk of the development of late onset Alzheimer's disease (AD), develop AD at an earlier age and experience a more severe cognitive decline and shorter survival time. The ?4 allele has been linked to the severity of the hippocampal atrophy and pathological changes in the cerebral cortex. ?2 allele is thought to exercise protection against the disease.

"Atrophy of the hippocampus, a region of the brain crucial is a common feature of the display for storage, although it can be demonstrated in the asymptomatic persons as well as healthy adults carrier of the ?4 ApoE allele", said Andy Simmons, PhD, of the Department of neuroimaging of the Institute of Psychiatry of at King's College London. "If young people manifest early changes genetically at risk for AD an important question for the procedures or treatments designed to slow or the progression of the disease keeps interested."

To resolve the question, 1412 teenagers underwent MRI imaging and had tested blood samples for DNA analysis to determine their ApoE status. "In contrast to some recent studies no hippocampal volume differences between carrier and carrier of the ApoE-?4 all Elle observed", said Dr. Simmons. The investigators also other possible changes, such as hippocampal asymmetry or saw gene dose-dependent effects on volume, but could find no associations with genetic status.

In addition to structural changes in patients with AD show in the brain usually an increase in the brain strain of amyloid-ß (insoluble) peptides and a decrease in the cerebrospinal fluid (CSF) concentration of insoluble peptides. Similar changes can be found in almost all people with mild cognitive impairment risk conversion to AD. "This changes the earliest diagnostic tools in AD, dar", explains Professor Dr. med. Piotr Lewczuk, head of the laboratory of clinical neurochemistry, and neurochemical dementia diagnosis at the University Clinic for Psychiatry and psychotherapy, Universittsklinikum Erlangen, Friedrich-Alexander University Erlangen Board. Because to a certain extent, also changes the concentrations of insoluble peptide in the blood are observed, his research group investigates differences in the plasma levels of insoluble peptides among young adults e4, e3 and e2 providers.

To determine whether these changes are associated AD available at an early age before clinical symptoms are visible, investigators measured insoluble peptide concentration in the plasma of 175 cognitively normal young adults. 40 employees (22.9%) had at least one e4 allele and were the e3/e3 genotype had "endangered" for AD, 111 (63.4%) and were called "neutral" and 24 (13.7%) in the "protected: Group had at least one e2 allele."

The investigators measured four insoluble peptide and determined that no significant differences in any of the insoluble peptide plasma levels were found between the three genetic groups.

"The lack of differences of the insoluble concentration reported in this study between the groups with and without increased genetic risk for AD does not mean that the ongoing preclinical Neurodegeneration in all young subjects, can be completely excluded", says Dr. Lewczuk. He also notes that approximately 40% of AD patients of not bearing the e4 allele are. He considers, however, that findings of hippocampal volume and its study of plasma concentrations set Dr. Simmons insoluble near, that the AD-suggestive changes maybe 20-30 years before the onset of clinical symptoms, but probably not before start most.



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